The Impact of Esmolol Administration on Postoperative Recovery

Last updated: October 25, 2022
Sponsor: Aretaieion University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chronic Pain

Acute Pain

Pain

Treatment

N/A

Clinical Study ID

NCT05567822
89/24-03-2022
  • Ages 18-75
  • All Genders

Study Summary

The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • adult patients
  • American Society of Anesthesiologists (ASA) classification I-II
  • elective inguinal hernia repair

Exclusion

Exclusion Criteria:

  • body mass index (BMI) >35 kg/m2
  • β-blocker administration preoperatively
  • systematic use of analgesic agents preoperatively
  • chronic pain syndromes preoperatively
  • neurological or psychiatric disease on treatment
  • pregnancy
  • severe hepatic or renal disease
  • history of cardiovascular diseases/ arrhythmias/ conduction abnormalities
  • hemodynamic instability
  • drug or alcohol abuse
  • language or communication barriers
  • lack of informed consent
  • bilateral inguinal hernia repair

Study Design

Total Participants: 70
Study Start date:
October 01, 2022
Estimated Completion Date:
October 01, 2024

Study Description

Contemporary anaesthesiology requires the quest of ways to restrict the use of opioids, which aim at the alleviation of severe postoperative and chronic pain. This is not only due to the side effects involved but also to the epidemic dimensions their use entails. Esmolol, an extremely short-acting cardioselective antagonist of β1 adrenergic receptors, is effectively used in order to attenuate the stress response and minimize undesirable perioperative hemodynamic changes. More specifically, esmolol has been used effectively to reduce pain during induction of anesthesia with propofol and treat tachycardia and hypertension during laryngoscopy. However, recent studies also highlight a possible antinociceptive and/or analgesic effect of esmolol. Therefore, The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain

Connect with a study center

  • Evangelismos General Hospital

    Athens, 10676
    Greece

    Active - Recruiting

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