Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI)

Last updated: July 21, 2025
Sponsor: Unity Health Toronto
Overall Status: Completed

Phase

1

Condition

Memory Loss

Dementia

Mental Disability

Treatment

Neuro RX Gamma device

Sham Neuro RX Gamma device

Clinical Study ID

NCT05563298
REB 22-128
  • Ages 50-95
  • All Genders

Study Summary

Over 50 million people worldwide are currently living with dementia-a number projected to rise to 152 million by 2050. Mitochondrial dysfunction in the brains of individuals with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) has gained increasing attention as a potential mechanism and therapeutic target. However, no effective treatment specifically targeting mitochondrial function is currently available.

Photobiomodulation (PBM) is an innovative, non-invasive technique that delivers near-infrared light transcranially to the brain. PBM is believed to enhance mitochondrial function-particularly in tissues with high mitochondrial density such as the brain-by reducing oxidative stress and increasing ATP production. It can be safely administered to awake outpatients and does not require general anesthesia or surgical intervention. While preclinical and case studies suggest PBM may be beneficial in AD, the absence of placebo-controlled trials and objective biomarkers has limited understanding of its effectiveness and underlying mechanisms.

Objectives: This pilot feasibility study aims to assess cognitive outcomes and neural correlates associated with PBM in individuals with early amnestic MCI (aMCI). Participants who meet eligibility criteria (n = 20) will undergo a 6-week, home-based PBM intervention using the Neuro Rx Gamma device (6 days/week, 20 minutes/session). Clinical and cognitive assessments, blood sample collection, and structural and resting-state functional MRI scans will be conducted at two time points: baseline and post-treatment. These assessments will enable evaluation of PBM's effects on cognition and brain function, with particular focus on mitochondrial-related mechanisms.

This study offers a unique opportunity to investigate whether PBM can modulate mitochondrial and neural processes associated with cognitive decline in aMCI.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age is greater than or equal to 50 years old.

  • Meets the National Institute on Aging and Alzheimer's Association (NIA-AA) criteriafor MCI due to Alzheimer's disease.

  • Essentially normal functional activities as derived from the CDR.

  • If receiving ongoing cholinesterase inhibitor therapy and/or memantine, must be on astable dosage for at least the prior 3 months.

  • MoCA score between 19 and 25 at screening assessment and impairment in learning andmemory domain.

Exclusion

Exclusion Criteria:

  • Cannot tolerate blood draws.

  • Claustrophobia (fear of small or enclosed spaces), that cannot tolerate MRIscanners.

  • A pace-maker or other metal implants that would preclude safe use of MRI.

  • DSM 5 diagnosis of alcohol or other substance use disorders within the past 12months.

  • Unstable medical illness, (e.g., uncontrolled diabetes mellitus or hypertension).

  • Any history of stroke, seizures, MS, light sensitivity or Lyme disease.

  • Any issues with ambulation, vision, or hearing which could, in the opinion of theinvestigator, interfere with their ability to complete assessments.

  • Participant or caregiver does not speak English at a level necessary for thecompletion of the assessments.

  • Has not completed at least a grade eight education, as necessary for the completionof the assessments.

  • Currently participating in another clinical research study involving aninvestigational product.

  • History of significant agitation and/or aggression, epileptic seizures.

  • Current neurologic disease affecting cognition other than Alzheimer's disease.

  • Photosensitivity reactions to sunlight or visible light (polymorphous lighteruption, solar urticaria, persistent light reactivity).

  • History of recurrent epistaxis within the last 24 weeks or currently taking majoranti-coagulants (including warfarin, low molecular weight heparin)

  • Increased skin sensitivity at the treatment site including active herpes simplex inthe treatment area, history of keloid formation, or history of retinoid use in thepast month.

  • Pregnant or lactating or planning to become pregnant.

  • Currently undergoing light therapy treatment.

  • Any reason that, in the opinion of the investigator, might place a participant atunacceptable risk for participation in the trial.

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: Neuro RX Gamma device
Phase: 1
Study Start date:
March 28, 2023
Estimated Completion Date:
February 03, 2025

Study Description

Intervention:

The experimental intervention will be the Vielight Neuro RX Gamma photobiomodulation (PBM) device, which delivers near-infrared light via five light-emitting diodes (LEDs) operating at a wavelength of 810 nm. The LEDs are positioned equidistantly on the scalp and intranasally to target key brain regions. The device generates no significant heat, enabling the use of an indistinguishable sham device for placebo control.

All participants will self-administer 20-minute sessions once daily, six days per week, for six weeks. Subjects and/or caregivers will receive training to ensure proper at-home use and will be asked to maintain a treatment diary to monitor adherence.

Assessments:

Each participant will undergo two in-person visits-at baseline (T0) and post-intervention (week 7; T2)-to complete the following evaluations:

Mini-Mental State Examination (MMSE) California Verbal Learning Test - Long Delayed Free Recall (CVLT-LDFR) Trail Making Test A and B (TMT-A, TMT-B)

Pittsburgh Sleep Quality Index (PSQI) Mild Behavioral Impairment Checklist (MBI-C) Blood tests: lactate and lactate-to-pyruvate (L/P) ratio Structural and resting-state functional MRI, 1H-MRS, CBF An additional safety check will be conducted at week 1, 3, 5, and at the end of the study (either remotely or in person).

Safety Endpoints:

Serious adverse events (SAEs), regardless of device causality Device-related adverse events (AEs) Rates of epistaxis (nosebleeds) and nasal infections

Connect with a study center

  • St Michael's Hospital

    Toronto, Ontario M5B 1W8
    Canada

    Site Not Available

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