CBD (Cannabidiol) Intraoral Application and TMD (Temporomandibular Disorders)

Last updated: July 20, 2023
Sponsor: Medical University of Silesia
Overall Status: Active - Recruiting

Phase

2/3

Condition

Corticobasal Degeneration

Muscle Pain

Dyskinesias

Treatment

5% polymer gel with CBD application

Placebo intervention

10% polymer gel with CBD application

Clinical Study ID

NCT05562635
CBD (Cannabidiol)
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The aim of the project is to assess the effectiveness of reducing the masseter muscles tension and hyperactivity in patients with a painful form of TMD by using polymers containing CBD compared to placebo polymers.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient agreement to participate into the research study
  • Age ≥18 and ≤ 60
  • Good general health,
  • Temporomandibular disorder-positive RDC/TMD examination for group Ia and Ib
  • Presence of all teeth (with the exception of the third molars)

Exclusion

Exclusion Criteria:

  • Cannabis cream/ placebo cream allergy
  • Hypersensitivity to substances to be used in the study
  • Wounds intra oral cavity
  • Addiction to cannabis
  • Patients being treated with analgesic drugs and/or drugs that affect muscle function

Study Design

Total Participants: 30
Treatment Group(s): 3
Primary Treatment: 5% polymer gel with CBD application
Phase: 2/3
Study Start date:
July 18, 2023
Estimated Completion Date:
August 30, 2023

Study Description

Since the healing properties of CBD have been known for a long time, the assumption of the proposed research is to reduce the tension of the masseter muscles, reduce the bruxism index and occlusal strength, as well as reduce pain, from which patients with TMD suffer.

CBD intraoral application therapy seems promising in that field. Patients attending The Department of TMD in Zabrze, Polska will be randomly divided into two groups: experimental and placebo. sEMG activity values will be compared during 14 and 30 days therapy with polymers. the efficacy of the cannabis cream used in the study. Positive results will confirm the efficacy of CBD relaxing properties used in the study, compared to placebo.

Connect with a study center

  • Department of TMD

    Zabrze, 41-800
    Poland

    Active - Recruiting

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