Phase
Condition
Pneumonia
Acute Respiratory Distress Syndrome (Ards)
Respiratory Failure
Treatment
Venovenous ECMO
Clinical Study ID
Ages 18-65 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Patients ≥18 to 65 years old
Acute hypoxemic respiratory failure characterised by new or worsening respiratorysymptoms developing within 2 weeks prior to the onset of need for oxygen orrespiratory support
Mechanical ventilation of <7 days
Moderate to severe respiratory failure, as demonstrated by two P:F ratios <150mmHgat least 6 hours apart. Arterial Blood Gases (ABG) with P:F ratio > 150mmHg arepermitted between the two trial inclusion ABGs.
Trial of proning (unless contraindicated)
Exclusion
Exclusion Criteria:
The patient will be extubated today or tomorrow (i.e. will not remain intubated andventilated the day after tomorrow)
Cardiogenic cause of respiratory failure
Chronic hypercapnic respiratory failure defined as PaCO2 > 60 mmHg in the outpatientsetting
Home mechanical ventilation (non-invasive ventilation or via tracheotomy) except forCPAP/BIPAP used solely for sleep disordered breathing
Confirmed diffuse alveolar haemorrhage from vasculitis
Neurologic conditions, i.e. undergoing treatment for intracranial hypertension
Currently receiving any form of ECMO (e.g., venovenous, venoarterial, or hybridconfiguration)
Patient needing immediate VV ECMO (as per EOLIA criteria)
The patient is moribund and deemed unlikely to survive past 24 hours (as determinedby the clinical team)
The patient is being transitioned to palliative care
Contraindications to anticoagulation (e.g., active GI bleeding, bleedingpredisposition, severe trauma)
Previous hypersensitivity/anaphylactic reaction to heparin or heparin-inducedthrombocytopenia
Participation or Consent is declined, OR
Unable to identify or Contact surrogate decision maker.
Study Design
Study Description
Connect with a study center
St Vincent's Hospital Sydney
Darlinghurst, New South Wales 2010
AustraliaActive - Recruiting
Royal Prince Alfred
Sydney, New South Wales
AustraliaActive - Recruiting
The Prince Charles Hospital
Brisbane, Queensland
AustraliaActive - Recruiting
Gold Coast University Hospital
Gold Coast, Queensland 4217
AustraliaActive - Recruiting
The Alfred Hospital
Melbourne, Victoria 3004
AustraliaActive - Recruiting
Fiona Stanley Hospital
Perth, Western Australia 6150
AustraliaSite Not Available
Charite Universitatmedizin
Berlin, 10117
GermanyActive - Recruiting
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