Dual-antiplatelet Therapy Strategies for Elective PCI in a Real-world Setting

Last updated: April 23, 2024
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Overall Status: Active - Recruiting

Phase

N/A

Condition

Coronary Artery Disease

Vascular Diseases

Atherosclerosis

Treatment

N/A

Clinical Study ID

NCT05559918
AUMC25485
  • Ages > 18
  • All Genders

Study Summary

To assess the safety and efficacy of in-laboratory clopidogrel loading dose administration before ad-hoc PCI versus clopidogrel preloading treatment in patients planned for diagnostic angiography with optional ad-hoc PCI.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult men and women aged at least 18 years
  • Scheduled for diagnostic CAG due to suspected obstructive coronary artery disease

Exclusion

Exclusion Criteria:

  • Presence of contra-indications for the use of clopidogrel (hypersensitivity or knownallergy to clopidogrel, severe liver insufficiency, resent or active pathologicalbleeding, patients known to be poor CYP2C19 metabolizers, patients usingpharmacological CYP2C19 inhibitors and inducers)
  • Patients using clopidogrel for other reasons than the scheduled diagnostic CAG (e.g.due to previous stroke)
  • Patients using P2Y12 inhibitors other than clopidogrel (e.g. prasugrel, ticagrelor,cangrelor)
  • Patients using VKA (e.g. acenocoumarol, fenprocoumon)
  • Patients using DOAC/NOAC (e.g. apixaban, dabigatran, edoxaban, rivaroxaban)
  • Inability to give informed consent (e.g., language barrier)
  • Patients who have a documented mentioning of previous denial to any trialparticipation in the electronic patient dossier

Study Design

Total Participants: 1462
Study Start date:
October 01, 2022
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • Amsterdam Universitair Medisch Centrum (AUMC) - Locatie AMC

    Amsterdam, Noord-Holland
    Netherlands

    Active - Recruiting

  • Amsterdam Universitair Medisch Centrum (AUMC) - Locatie VUMC

    Amsterdam, Noord-Holland
    Netherlands

    Active - Recruiting

  • Amsterdam Universitair Medisch Centrum (AUMC) - Lokatie VUMC

    Amsterdam, Noord-Holland
    Netherlands

    Site Not Available

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