The Effect of Magnesium Use in Reversal of Neuromuscular Block With Sugammadex

Last updated: May 26, 2025
Sponsor: Eskisehir Osmangazi University
Overall Status: Completed

Phase

N/A

Condition

Pregnancy Complications

Treatment

pregnant women taking magnesium

Placebo

Clinical Study ID

NCT05558969
ESOGU 4
  • Ages 18-65
  • Female

Study Summary

Magnesium therapy used for seizure prophylaxis in patients with preeclampsia. Magnesium has been shown to prolong the effect of nondepolarizing neuromuscular blocking agents (NMBA) and neostigmine used to reverse the effect of NMBA in general anesthesia . In this study, the investigators aimed to evaluate time from sugammadex injection to Train-of-four ratio 0.9 who receieved magnesium therapy in reversing the effect of neuromuscular blocking agent during the recovery period and the relationship between magnesium level and duration of action of sugammadex

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pregnant women who are scheduled for cesarean section under general anesthesia (pregnant women who do not use magnesium) and who use magnesium for prophylaxis inpreeclampsia.

Exclusion

Exclusion Criteria:

  • Eclampsia,

  • chronic hypertension,

  • connective tissue disorder,

  • muscle disease, neurological problems,

  • thyroid dysfunction,

  • kidney disease, heart disease,

  • patients with severe allergic reaction to the agents to be used,

  • sepsis,

  • hypovolemia, abruptio placenta, placenta previa,

  • conditions that will prolong the effect of muscle relaxants (drug use ),

  • pregnant women who did not want to be included in the study

Study Design

Total Participants: 30
Treatment Group(s): 2
Primary Treatment: pregnant women taking magnesium
Phase:
Study Start date:
September 28, 2022
Estimated Completion Date:
May 26, 2025

Study Description

Rapid-onset and short-acting agents should be preferred in induction, and full induction doses should be applied since they do not receive premedication and increased volume of distribution. Rapid serial induction and intubation should be performed in pregnancies greater than 20 weeks due to the risk of aspiration. Magnesium potentiates and prolongs the effect of nondepolarizing neuromuscular blocking agents. It is recommended that the TOF value be between 0 and 2 for adequate muscle relaxation in cesarean section anesthesia. In anesthesia induction; thiopental 3-6mg/kg, rocuronium 1mg/kg, and fentanyl 1mcg/kg and dormicum 2mg will administered after the baby birth. Sevoflurane 2-3% and 50% oxygen + 50% air are used for maintenance. If TOF is 0, sugammadex 4mg/kg will be administered to reverse the effect of the muscle relaxant.A blood sample will be taken to measure simultaneous calcium and magnesium values. Patients with a TOF ≥0.9 (gold standard for extubation) or patients will be clinically evaluated and the decision to extubate will be made.

Connect with a study center

  • Eskisehir Osmangazi Universıty Faculty of Medicine

    Eskisehir, Eski̇şehi̇r 26040
    Turkey

    Site Not Available

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