Effect of Laparoscopic Cholecystectomy on Risk of Metabolic Syndrome

Last updated: September 27, 2022
Sponsor: Brothers Hospitallers Hospital in Cracow
Overall Status: Active - Recruiting

Phase

N/A

Condition

High Cholesterol (Hyperlipidemia)

Metabolic Syndrome

Liver Disorders

Treatment

N/A

Clinical Study ID

NCT05557669
1072.6120.25.2021
  • Ages 18-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Prospective cohort study. POPULATION: patients with gallstone disease qualified for laparoscopic cholecystectomy INTERVENTION: patients undergoing cholecystectomy for gallstones COMPARISON: gallstone disease without surgery in an observation period OUTCOME: metabolic syndrome symptoms evaluated in 3 months period The main inclusion criteria is cholelithiasis confirmed by ultrasound examination in patients between 18-75 years old. The main exclusion criteria are metabolic syndrome, diabetes, thyroid diseases, pancreatic diseases, serious abdominal surgeries in the past, pregnancy, and lactation. Participants who qualified for laparoscopic cholecystectomy in 3 months are included in the investigation group. Those not having cholecystectomy planned in the upcoming three months for any reason (no consent for surgery, long term) are included in the control group. The intervention is to assess all metabolic syndrome criteria (blood pressure, glucose tolerance, dyslipidemia, abdominal obesity) before and three months after surgery. The endpoint is to evaluate if the risk of metabolic syndrome after cholecystectomy is higher than in patients with gallstones.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • cholelithiasis

Exclusion

Exclusion Criteria:

  • metabolic syndrome
  • obesity
  • diabetes
  • thyroid disease
  • pancreatic disease
  • serious abdominal surgeries in the past
  • pregnancy, lactation

Study Design

Total Participants: 400
Study Start date:
February 17, 2021
Estimated Completion Date:
March 30, 2025

Study Description

Laparoscopic cholecystectomy is well known as a gold standard of treatment for gallstone disease. Gallbladder removal is one of the most common procedures in the United States, with more than 1.2 million cholecystectomies per year, and 92% of the procedures are performed laparoscopically. In 2011 Amigo et al. reported increased triglyceride levels in mice after cholecystectomy. According to Ruhl et al. (2013), cholecystectomy is associated with an increased risk of non-alcoholic fatty liver disease that is considered a liver manifestation of metabolic syndrome. In 2014, Shen et al. published a retrospective study enrolling 5672 participants that demonstrated an increased risk of metabolic syndrome after cholecystectomy compared with gallstone disease alone. Metabolic syndrome (MS) is a disease of civilization. It is a group of disorders containing impaired glucose intolerance, hypertension, abdominal obesity, and dyslipidemia. According to meta-analysis, individuals reaching the criteria of metabolic syndrome have a twice higher risk of myocardial infarction or stroke and a 1,5-times higher risk of death for any reason. The study aims to assess the risk of metabolic syndrome after laparoscopic cholecystectomy prospectively.

Connect with a study center

  • Brothers Hospitallers Hospital in Cracow

    Kraków, Lesser Poland 31061
    Poland

    Active - Recruiting

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