Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.

Last updated: December 29, 2023
Sponsor: University of Milano Bicocca
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Inflammation

Red Blood Cell Disorders

Treatment

N/A

Clinical Study ID

NCT05553873
INFLA-ME
  • Ages 18-99
  • All Genders

Study Summary

This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years at the time of diagnosis of MPN Ph negative
  • Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO orIWG-MRT criteria (diagnosis since 2000)
  • Obtaining informed consent

Exclusion

Exclusion Criteria:

  • Life expectancy of less than 6 months
  • Accelerated phase myelofibrosis or MPN with signs of leukemic evolution

Study Design

Total Participants: 500
Study Start date:
September 08, 2022
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Azienda Ospedaliera Universitaria Consorziale Policlinico

    Bari,
    Italy

    Active - Recruiting

  • Policlinico Sant'Orsola Malpighi

    Bologna,
    Italy

    Active - Recruiting

  • ASST Spedali Civili di Brescia

    Brescia,
    Italy

    Active - Recruiting

  • Policlinico Vittorio Emanuele

    Catania,
    Italy

    Active - Recruiting

  • Ospedale Universitario Federico II

    Napoli,
    Italy

    Active - Recruiting

  • Policlinico Umberto I, Università La Sapienza

    Roma,
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Città della Salute e delle Scienza

    Torino,
    Italy

    Active - Recruiting

  • Ospedale San Luigi di Orbassano - Ospedale Mauriziano

    Torino,
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Friuli Centrale

    Udine,
    Italy

    Active - Recruiting

  • Azienda Ospedaliera Universitaria Integrata

    Verona,
    Italy

    Active - Recruiting

  • Ospedale Belcolle

    Viterbo,
    Italy

    Active - Recruiting

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