Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease

Inclusion Criteria:

->18 years of age

• Advanced liver disease

• Able to give written, informed consent

• Alcohol as a cause of advanced liver disease

• Continued sustained drinking

• Having previously declined a referral to traditional AUD therapy services or havingfailed such treatments

Exclusion Criteria:

• Lack of sustained drinking

• Recent or current alcoholic hepatitis

• Alcohol withdrawal symptoms

• Clinically significant use of illicit drugs

• Uncontrolled mood disorders or primary psychotic conditions

• MELD score>17

• Unclear diagnosis of chronic liver disease

• Current hepatic encephalopathy on lactulose and/or rifaximin

• WBC count<1000

• Non-elective hospitalization within last month

• on dialysis

• known untreated, in-situ luminal GI cancers

• chronic intrinsic GI diseases (ulcerative colitis, Crohn's disease or microscopiccolitis, eosinophilic gastroenteritis and celiac disease)

• Dysphagia within 2 weeks

• History of aspiration, gastroparesis, intestinal obstruction

• Ongoing absorbable antibiotic use

• Severe anaphylactic food allergy

• allergy to ingredients Generally Recognized As Safe in the G3 capsules (glycerol,sodium chloride, hypromellose, gellan gum, titanium dioxide, theobroma oil)

• Adverse event attributable to prior IMT

• ASA Class IV or V

• Pregnant or nursing patients

• acute illness or fever on the day of planned FMT

• Immunosuppression

• Other conditions which make patients are poor candidate for this study perinvestigator judgement