Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients with Exudative AMD (SINE)

Last updated: February 11, 2025
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sinusitis

Macular Degeneration

Treatment

sinusitis screening consultation

Clinical Study ID

NCT05547633
RLX-2022-4
  • Ages > 18
  • All Genders

Study Summary

An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis.

Some patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis.

The investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years

  • Patient followed and treated for at least 2 years for bilateral neovascular form ofage-related macular degeneration (AMD)

  • At least one eye treated with ≥ 6 intravitreal injections during the year precedingpreinclusion

  • Express consent to participate in the study

  • Affiliated with or beneficiary of a social security plan

Exclusion

Exclusion Criteria:

  • Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to allprotected persons: pregnant women, parturients, nursing mothers, persons deprived ofliberty by judicial or administrative decision, minors, and persons under legalprotection: guardianship or curatorship).

  • Severe myopia (> 6 diopters)

  • Patient already being treated for acute or chronic sinusitis

  • History of central serous chorioretinopathy or diffuse retinal epitheliopathy

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: sinusitis screening consultation
Phase:
Study Start date:
January 20, 2023
Estimated Completion Date:
April 30, 2028

Connect with a study center

  • Hôpital Fondation A. de Rothschild

    Paris, 75019
    France

    Active - Recruiting

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