the Safety and Effectiveness of Precise rTMS Based on Neuroimaging in the Treatment of Adolescent Depression With Anhedoniadepression With Anhedonia

Inclusion Criteria:

• Male or female, 13 to 18 years of age.
• According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition,Diagnosed with Major Depressive Disorder (MDD) and currently experiencing a MajorDepressive Episode (MDE).
• Meet the threshold on the total HAMD17 score of >/=17 at both screening and baselinevisits (Day -7 and Day 0).
• Meet the threshold on the total SHAPS score of >/=20 at both screening and baselinevisits (Day -7 and Day 0).
• Not take any antidepressants for two or more weeks before screening.
• In good general health, as ascertained by medical history.
• After fully understanding the treatment of transcranial magnetic stimulation, willingto cooperate with the treatment actively and able to provide informed consent.

Exclusion Criteria:

• Current diagnosis of a Substance Use Disorder, with the exception of nicotine andcaffeine dependence.
• Current diagnosis of mental disorders other than Dysthymic Disorder, GeneralizedAnxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, or SpecificPhobia (unless one of these is clinically unstable, and/or the focus of theparticipant's treatment for the past six months or more).
• History of schizophrenia or schizoaffective disorders, or any history of psychoticsymptoms in the current or previous depressive episodes.
• Any other Mental Disorders, Personality Disorders, Intellectual Disability, which atscreening is clinically predominant to their MDD.
• Has a clinically significant abnormality on the screening examination that mightaffect safety, study participation, or confound interpretation of study results.
• Any current or past history of any physical condition which in the investigator'sopinion might put the subject at risk or interfere with study results interpretation.
• Participation in any clinical trial with an investigational drug or device within thepast month or concurrent to study participation.
• History of electronic instrument or metal in the head or skull.
• History of epilepsy.
• History of cardiovascular disease or cardiac event.
• History of OCD.
• History of autism spectrum disorder.
• History of rTMS exposure.
• Other situations judged by the researchers to be unsuitable for the study.