Nutrition for Brain and Body Health (BB-Health) Feasibility Trial

Major inclusion criteria:

1. Adult women and men aged 55-85 years.

2. BMI of 27.0-39.9 kg/m2 at screening (higher BMIs not included at this time tofacilitate program adherence);

3. Scores of 34 or greater on the Modified Telephone Interview for Cognitive Status (TICS-M) at screening (85). The purpose of this screen is to ensure thatparticipants can give consent and adhere to the study requirements, including theoutcomes testing.

4. Willing to be randomized and participate in all study components, includingconsuming the foods and supplements, participating in the WL intervention or controlmeetings, being available for outcome assessments, using the provided home Wi-Fiscale and activity monitor daily, and completing questionnaires, as well asproviding the login information for scales and activity monitor so investigators candownload the data.

5. Satisfactory screening review of health history questionnaire by nursing staff forrelevant factors including no evidence of exclusions listed below. This will includeverbal confirmation of completing a course of vaccination against COVID-19 (twodoses plus one booster prior to screening visit). The reason for this studycomponent is that live group meetings are planned with other participants, and thiswill reduce participant risk.

6. Has access to computer or smartphone with Wi-Fi and possesses a freezer at home withspace for supplement storage.

7. Rates representative food with characteristics of the MCNS and control foods atleast 4 on a 5-point scale of liking at screening, and reports that they are willingto consume the food daily.

8. Average energy intake in 3 24-h dietary recalls is within physiological (i.e.,plausible) range.

Major exclusion criteria:

1. >25% percentile in most recent data for US adult population intake for reportedDHA/EPA in screening questionnaire for rich food sources, which is equivalent to 2or more servings of fatty fish/month (86, 87).

2. Regularly taking a multivitamin, cacao/cocoa supplement, choline supplement, DHA/EPAsupplement, or any supplement advertised for brain health or cognitive function (>1/week). Washout period of 2 months accepted.

3. Does not like, or alternatively reports eating >1 serving per week of >60% chocolateor cocoa.

4. Severe cardiovascular disease including stroke, heart failure, coronary bypass andvalve replacement, coronary bypass or any surgical procedures or signs and symptomsof current severe cardiovascular disease.

5. History of neurological brain disease, including stroke, seizure disorders,traumatic brain injury (moderate to severe); including prior diagnosis of aneurodegenerative disease including AD and Parkinson's disease, frontotemporaldementia. Moderate traumatic brain injury is defined by an injury with loss ofconsciousness.

6. Major psychiatric disorder history (schizophrenia, bipolar affective disorder,intractable depression).

7. Inadequately controlled hypertension at the discretion of study MD or RN

8. Diabetes Type 1 & Type 2 or use of any pharmacological treatment for diabetes orHbA1c >6.5 at screening.

9. Any disorder, unwillingness, or inability, not covered by any of the other exclusioncriteria, which in the investigator's opinion, might jeopardize the subject's safetyor compliance with the protocol. This includes the lost of smell or taste.

10. History of stomach or bowel resection (other than appendectomy), gastric bypass, orother bariatric weight loss procedure

11. GI diseases, conditions or meds known to influence GI absorption including activepeptic ulcer disease or inflammatory bowel disease (such as ulcerative colitis,Crohn's disease), Celiac disease, Cystic Fibrosis, malabsorption disorders,gallbladder disease, acute or chronic pancreatitis or Pancreatic insufficiency

12. Chronic kidney disease or history of kidney stones

13. History of diagnosed eating disorder anorexia, bulimia or binge-eating

14. Active treatment for cancer (except non-melanoma skin cancer) of any type in ≤ 3year.

15. Thyroid disease or other significant endocrine disorder

16. Uncontrolled hypercholesterolemia.

17. History of acute or chronic pancreatitis or gall bladder disease.

18. Metabolic disorders or conditions that interfere with nutrient absorption (such asPhenylketonuria, Maple Syrup Urine Disease, glucose-galactose malabsorption,ornithine transcarbamylase deficiency or hypophosphatemic rickets.)

19. Dose adjustment to statin or antihypertensive medication within the past 3 months

20. Screening lab results outside the normal parameters that may interfere with studyoutcomes at the discretion of study MD

21. Inadequate venous access or history of a bilateral mastectomy with nodal dissection

22. Recent history of inflammatory diseases (for example: rheumatoid arthritis, lupus)

23. Active WL, or weight change > 4 kg in past 6 months.

24. Consuming a restrictive diet (e.g. gluten-free, vegan, Paleolithic diet).

25. Self-reported allergy to any ingredient in the provided intervention foods.

26. Self-reported severe allergy to adhesives.

27. Unwilling to use a mobile phone or computer with videoconference software toparticipate in intervention group meetings. Unwilling to eat on camera.

28. Reports of consumption of > 2 alcoholic drinks per day on average or >14/week (168ozbeer/56oz wine/14oz hard liquor.)

29. Reports of consumption of > 2 cups of green or black tea per day on average.

30. Reports of use of recreational and/or illegal drugs.

31. Regular smoking or vaping tobacco or marijuana including the use of edibles withinthe last 6 months (greater than once a week)

32. Non-English speakers.

33. No social security number (required for stipend payment).