A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Inclusion Criteria:

All participants with or without diabetes:

• Have a Body Mass Index (BMI) ≥27 kilogram/square meter (kg/m²) at screening

• Diagnosed with chronic kidney disease (CKD)

• Has an estimated glomerular filtration rate (eGFR) ≥25 to ≤60 ml/min/1.73 m² or eGFR ≥25 to ≤75 ml/min/1.73 m² if urine albumin-to-creatinine ratio (UACR) >30milligram/gram (mg/g)

• Have been receiving an angiotensin-converting enzyme (ACE) or angiotensin IIreceptor blockers (ARB) that is considered the maximal appropriate dose by theinvestigator for treatment of chronic kidney disease or hypertension (unless theparticipant has low blood pressure or hypotension)

Participants without diabetes:

• Have Hemoglobin A1c (HbA1c) <6.5% at screening

Participants with Type 2 diabetes:

• Have been diagnosed at least 180 days prior to screening

• Have HbA1c ≤9.5% at screening

Exclusion Criteria:

All participants:

• Have a self-reported change in body weight >5 kilogram (kg) within 90 days prior toscreening.

• Have a prior or planned surgical treatment for obesity

• Have or plan to have endoscopic and/or device-based therapy for obesity or have haddevice removal within the last 180 days

• Have eGFR <25 mL/min/1.73m² calculated by using creatinine-based chronic kidneydisease epidemiology collaboration (CKD-EPI) equations, as determined by centrallaboratory at screening.

• Have a history of unstable or rapidly progressing renal disease according toinvestigator judgment

• Have a known clinically significant gastric emptying abnormality (for example,severe diabetic gastroparesis or gastric outlet obstruction) or chronically takedrugs that directly affect GI motility)

• Have had a history of chronic or acute pancreatitis

Participants with T2D:

• Have history of proliferative diabetic retinopathy or diabetic macular edema ornon-proliferative diabetic retinopathy that requires acute treatment.

• Have been diagnosed with type 1 diabetes (T1D) or have history of ketoacidosis orhyperosmolar state/coma