Drug Discovery for Parkinson's with Mutations in the GBA Gene

Phase

N/A

Condition

Gaucher Disease

Treatment

Biological Sample Collection

Clinical Study ID

NCT05536388

10-008

Ages > 18
All Genders
Accepts Healthy Volunteers

Study Summary

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate Parkinson's disease research and drug development by using cells from the body (such as skin or blood cells) to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and/or store the samples for future use.

Through this research, researchers hope to identify future treatments or even cures for Parkinson's disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age 18 years or older.
Diagnosis of Parkinson's disease, Gaucher disease, or healthy control.
Must provide written informed consent unless physical limitations preclude signing.

Exclusion

Exclusion Criteria:

For skin samples collected specifically for this study: history of keloid formation,coagulation disorder, allergy to the anesthetic, or anticoagulation use thatprecludes sample collection.
For blood samples collected specifically for this study: coagulation disorder orother medical condition(s) that increases the risks associated with bloodcollection.
For all prospective sample collections: Subjects who refuse to adhere to NYSCF'sand/or a collection site's safety protocols will be excluded. Subjects with an AIDSdiagnosis and CD4 count of less than 200 cells per microliter (mcL) of blood will beexcluded due to increased risk of infection.

Study Design

Biological Sample Collection

July 15, 2022

July 15, 2025

Study Description

Researchers at the New York Stem Cell Foundation (NYSCF) Research Institute study diverse diseases, conditions, and traits by creating stem cells from biological samples. These "pluripotent" stem cells can become any cell in the human body, including cells that may be difficult, invasive, or impossible to obtain directly.

Additionally, researchers perform genetic testing to learn more about DNA, a material in most cells that contains instructions for the body's development and functions (such as traits like eye color and risk of certain diseases). A piece of DNA that determines the specific role of a cell is called a "gene." If the instructions in a gene are abnormal, this can lead to disease.

Participation in the study involves: (1) completion of health questionnaires, (2) providing a skin and/or blood sample from which stem cells may be created, (3) collection of a saliva sample for genetic analysis, and (4) possible future follow-up to provide additional information or learn about other research studies.

This study is not a clinical trial.

Connect with a study center

The New York Stem Cell Foundation Research Institute
New York, New York 10019
United States
Active - Recruiting

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