Corticosteroid Therapy for Persistent Synovitis in Acute Septic Arthritis on Native Joint

Last updated: May 10, 2023
Sponsor: University Hospital, Strasbourg, France
Overall Status: Active - Recruiting

Phase

N/A

Condition

Rheumatoid Arthritis

Arthritis And Arthritic Pain

Joint Injuries

Treatment

N/A

Clinical Study ID

NCT05531227
8654
  • Ages > 18
  • All Genders

Study Summary

Acute septic arthritis is a rare but life-threatening and functionally serious disease. The improvement or disappearance of pain and functional recovery are sometimes difficult to obtain, with in some cases the persistence of synovitis due to a prolonged local inflammatory response, despite early and effective treatment. The consequences are significant for patients with often significant chronic pain, repercussions on autonomy and/or profession. An unfavorable evolution with joint destruction and need for replacement by a prosthesis is not uncommon.

Corticosteroid therapy is widely used in rheumatology in similar tables, for the purpose of drug synovectomy, with good results. The risk of infection remains the main contraindication to its use.

There are very few studies on its use in septic arthritis, either fundamentally or in humans, for which there are no data in adults. However, these have shown results encouraging the investigators not to neglect this therapy.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Adult patient (≥18 years old)
  • having presented with septic arthritis and treated at the Strasbourg UniversityHospital between January 1, 2012 and December 31, 2021
  • clinical finding of persistent synovitis, defined by the presence of pain, effusion orjoint stiffness despite well-conducted treatment
  • having had a diagnosis of joint infection proven by a positive culture of the jointfluid to a pathogenic germ
  • having had treatment with local or systemic corticosteroids.

Exclusion

Exclusion criteria:

  • Patient who has expressed his opposition to the reuse of his data for scientificresearch purposes.
  • Absence of corticosteroid treatment

Study Design

Total Participants: 100
Study Start date:
June 20, 2022
Estimated Completion Date:
December 13, 2023

Connect with a study center

  • Service de Chirurgie Orthopédique Septique - CHU de Strasbourg - France

    Strasbourg, 67091
    France

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.