A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer

Inclusion Criteria:

• Have a confirmed diagnosis of adenocarcinoma of the prostate and are candidates forcurative-intent external beam radiation (with or without androgen deprivationtherapy, ADT) at the Wilmot Cancer Institute Department of Radiation Oncology.Radiotherapy may be either primary, adjuvant or salvage. It may be part of combinedtreatment with androgen deprivation therapy.

• Be stage M0 based on the standard of care staging imaging

• Be able to read English

• Have the psychological ability and general health that permits completion of thestudy requirements and required follow up

• Be ≥18 and < 70 years of age

• Have ECOG performance status of 0 to 2 within 180 days prior to enrollment

• Have adequate renal function with creatinine clearance > 30 mL/min within 30 daysprior to registration

• Have hematologic and hepatic function deemed adequate for planned treatment by thetreating investigator within 90 days prior to registration, including:

• hemoglobin ≥9.0 g/dL, independent of transfusion and/or growth factors

• platelet count ≥100,000/µL independent of transfusion and/or growth factors

• Have a baseline systolic blood pressure of >130.

Exclusion Criteria:

• Have received prior pelvic radiotherapy

• Be taking lisinopril or other RAS modifying drug within two months prior toregistration

• Have had a prior allergic reaction to lisinopril