Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: RIGHT-CRT

Inclusion Criteria:

• systemic right ventricle (SRV),

• CRT-P or CRT-D device implanted for at least 1 month,

• Age ≥18 years old,

• One of the two following CRT indications:

• NYHA II-IV, right ventricular ejection fraction ≤ 35% and spontaneous QRSduration ≥ 150 ms Or

• NYHAI-IV, atrioventricular conduction disorders with ventricular pacing > 40% (regardless right ventricular ejection fraction).

• Affiliation to a french social security system (beneficiary or legal)

• Informed and signed consent

Exclusion Criteria:

• Pregnancy or breastfeeding

• Women of childbearing potential who do not have a negative pregnancy test and do notuse one of the following methods of birth control: hormonal contraception orintrauterine device or bilateral tubal occlusion

• Patient benefiting from a measure of legal protection (guardianship, curatorship,under judicial safeguard, activated future protection mandate and familyauthorization),

• Cardiac surgery during the last 3 months or planned during the next 6 months,

• Percutaneous structural cardiac intervention planned during the next 6 months,

• Persistent atrial arrhythmia with catheter ablation planned during the next 6months,

• Acute congestive heart failure,

• Dysfunction of at least one CRT device lead that compromise biventricular pacing,

• Patient on AME

• Current participation in another interventional clinical study or being in theexclusion period at the end of a previous study.