Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Last updated: January 8, 2025
Sponsor: The University of Texas at Arlington
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aging

Low Blood Pressure (Hypotension)

Treatment

Alcohol Abstinence Intervention

Exercise Training

Clinical Study ID

NCT05522075
2200-0189
4R00AA028537-03
  • Ages 50-64
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study has two phases:

Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.

Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Men and women (50-64 years of age) who do not drink alcohol, who drink at moderatelevels, or who binge drink

  • Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).

  • Subjects who can speak and understand English.

Exclusion

Exclusion Criteria:

  • a history of diabetes, cardiovascular disease, liver, or renal disease

  • current or history of smoking and illicit drug use

  • blood pressure ≥160/100 mm Hg

  • other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), orhyperlipidemia (total cholesterol>230 mg/dl and/or LDL cholesterol>160 mg/dl)

  • active infection (in the past 2 months)

  • a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)

  • unstable body weight (>5% change during the past 6 months)

  • regular aerobic exercise training (i.e., they engage in 30 min of structured aerobicexercise at least 3 times per week)

  • current use of hormone replacement therapy (i.e., estrogen, progesterone, andtestosterone)

Study Design

Total Participants: 55
Treatment Group(s): 2
Primary Treatment: Alcohol Abstinence Intervention
Phase:
Study Start date:
November 21, 2022
Estimated Completion Date:
April 30, 2026

Study Description

During phase 1, we will measure blood pressure, microvascular function, and sympathetic nerve activity (baseline assessment) in mid-life adult binge drinkers, alcohol abstainers, and moderate drinkers. Only mid-life adult binge drinkers will enter Phase 2 and be randomized to the exercise training group and non-exercise control group. After 8 weeks of intervention, we will re-measure blood pressure, microvascular function, and sympathetic nerve activity (post-intervention assessment) in mid-life adult binge drinkers.

Connect with a study center

  • University of Texas at Arlington

    Arlington, Texas 76010
    United States

    Active - Recruiting

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