Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure

Last updated: December 16, 2024
Sponsor: University College, London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Panic Disorders

Anxiety Disorders

Obsessive-compulsive Disorder

Treatment

N/A

Clinical Study ID

NCT05520398
15/0541
  • Ages 18-55
  • All Genders

Study Summary

The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy.

To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of obsessive-compulsive disorder (OCD)

  • Fluent in written and spoken English

  • Normal/corrected to normal vision

  • Expecting to start OCD therapy

Exclusion

Exclusion Criteria:

  • Autism spectrum disorder, psychosis, schizophrenia, addiction, substance abuse,bipolar, hoarding, or Tourette disorder

  • Hearing conditions: tinnitus, ear inflammation, hearing sensitivity, hearing loss,requires hearing aids

  • Colour blindness

  • Severe learning disabilities

Study Design

Total Participants: 90
Study Start date:
November 10, 2021
Estimated Completion Date:
December 31, 2025

Study Description

A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP).

In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks).

To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms.

The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study.

Connect with a study center

  • Max Planck UCL Centre for Computational Psychiatry and Ageing Research

    London, WC1B 5EH
    United Kingdom

    Active - Recruiting

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