The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes

Last updated: May 20, 2024
Sponsor: University of Exeter
Overall Status: Completed

Phase

N/A

Condition

Diabetes Prevention

Diabetes And Hypertension

Treatment

Ketone - beta-hydroxybutyrate (β-OHB)

Clinical Study ID

NCT05518448
22-02-02-B-01
  • Ages 18-69
  • All Genders

Study Summary

What is the effect of a ketone drink on liver glucose production, and postprandial glycemia, in people with type 2 diabetes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed with type 2 diabetes by a physician, a current HbA1c of 6.5-8.5%, andreceiving treatment with lifestyle advice or oral glucose-lowering medications.

  • Non-smoking

  • Blood pressure <160/100 mm/Hg

Exclusion

Exclusion Criteria:

  • Exogenous insulin or SGLT2 inhibitors for type 2 diabetes treatment.

  • Following a low-carbohydrate ketogenic diet, periodic fasting diet, or consumingketogenic supplements.

  • Other diagnosed chronic metabolic, cardiovascular, respiratory, neurological, orgastrointestinal disease.

  • Smoker

  • Blood pressure >160/100 mm/Hg

  • Lactose intolerant

Study Design

Total Participants: 10
Treatment Group(s): 1
Primary Treatment: Ketone - beta-hydroxybutyrate (β-OHB)
Phase:
Study Start date:
May 03, 2022
Estimated Completion Date:
November 01, 2023

Study Description

Background: Ketones are molecules that are naturally produced by our body during fasting or diets low in carbohydrates. Ketones can affect how our liver produces and maintains our body's blood sugar levels, which could be important in the management of type 2 diabetes (T2D), where high blood sugar levels are partly because of excess sugar production by the liver.

Objectives: To determine if, and how, a ketone drink can lower blood glucose in people with T2D following a meal.

Methods: Twelve people with T2D will visit our laboratory in the morning on two occasions and ingest a drink containing ketones or placebo on each visit in a random order before ingesting a milkshake style drink containing sugar. Blood samples will then be taken at regular intervals over 4 hours to determine if the ketone drink has lowered blood sugar levels in response to the meal, and if this was due to reduced sugar production by the liver.

Value: This research will provide new knowledge about the regulation of liver blood sugar production in response to ketone ingestion. This may also inform future clinical trials to establish if ketone drinks could be used as a treatment for T2D.

Connect with a study center

  • Sport & Health Sciences, University of Exeter

    Exeter, Devon EX1 2LU
    United Kingdom

    Site Not Available

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