High-dose Chemotherapy+G-CSF in Peripheral Blood Stem Cell Mobilization in Patients With Multiple Myeloma

Inclusion Criteria:

• Confirmed MM patients: patients who were initially diagnosed and treated, who weresuitable for autologous transplantation and planned to be treated with ASCT;

• Age limitation: 18-70 years old patients; ④ Physical status: ECOG physicalstatus score was 0 or 1; ⑤ The adverse reactions caused by chemotherapy hadrecovered: peripheral blood leukocytes ≥3.0×109/L, hemoglobin ≥80g/L, platelet ≥80×109/L; Liver function glutamic-pyruvic transaminase and glutamic-oxalacetictransaminase ≤ 2 times the upper limit of normal value, total bilirubin ≤ 1.5times the upper limit of normal value, serum creatinine ≤ 1.5 times the upperlimit of normal value, chest CT normal, ecg normal; (5) Patients participatevoluntarily and informed consent is signed by patients themselves (or theirlegal representatives); Take effective contraceptive measures during thechildbearing age.

Exclusion Criteria:

① According to the clinical judgment of the researcher: According to NCI CTCAE (4th edition May 28, 2009), patients with ≥3 grade cardiopulmonary insufficiency and severe kidney disease, currently diagnosed as coronary heart disease, myocardial infarction, arrhythmia, glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase ≥ 2 times the upper limit of normal value, Total bilirubin ≥ 1.5 times the upper limit of normal;

• With active infection, including fever of unknown cause (axillary temperature > 37.5℃); ③ Patients with severe history of mental system.