The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

Phase

N/A

Condition

Post-surgical Pain

Chronic Pain

Acute Pain

Treatment

Ascorbic acid 100mg/kg, Maximus 10g

Ascorbic acid 5000mg

Control Rx

Clinical Study ID

NCT05514197

CMMC11104/016

Ages 50-80
All Genders

Study Summary

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Physical status according to American Society of Anesthesiologists (ASA) I-III
Patients scheduled for total knee arthroplasty
Patients aged ranging from 50 to 80 years old

Exclusion

Exclusion Criteria:

Previous operation on the same knee
Allergy or intolerance to one of the study medications
Coagulopathy
Having lower limbs neuropathy
End-organ failure (CKD stage IV or V, NYHA III or IV)
BMI > 35
Chronic opioid use (>3 months) or drug abuser
Difficulty in communication (Impaired mental status)
Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

Study Design