RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine

Inclusion Criteria:

1. Age ≥18 years;

2. Positive COVID-19 test by nasopharyngeal swab RT-PCR (reverse transcriptionpolymerase chain reaction) test, antibody or antigen tests at least 3 months priorto randomization; OR Presumed COVID-19 assessed by the site investigator (nopositive COVID-19 test) with acute illness after October 15, 2019.

3. Patients should be treated with standard of care therapies (as discussed in thestudy manual) for at least 4 weeks prior to entry into trial.

4. Lingering COVID-19 symptoms beyond 3 months from onset of acute COVID and symptomshave lasted at least 2 months. The onset of COVID is considered the earliest of twodates: the date of positive test or the date of first symptoms;

5. Lingering symptoms from COVID-19 present at the time of randomization.

6. Female patients of childbearing potential (as assessed by the overseeingInvestigator) who are sexually active must agree to practice true abstinence or useeffective methods of contraception while on study treatment. Effective methods ofcontraception must be discussed and approved by the overseeing Investigator.

7. Must be able to provide informed consent and both willing and able to comply withstudy requirements.

Exclusion Criteria:

1. Patients who had mechanical ventilation or extracorporeal membrane oxygen (ECMO) forCOVID-19;

2. Current end-organ failure, organ transplantation, or current hospitalization inacute care hospital;

3. Contraindications to all of the study interventions;

4. Co-enrolment in another interventional trial (co-enrolment in an observational studyis permitted);

5. Currently pregnant or breastfeeding.