Prone Positioning During Delayed Cord Clamping

Last updated: October 2, 2025
Sponsor: Johns Hopkins University
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

N/A

Treatment

Prone Positioning

Supine Positioning

Clinical Study ID

NCT05507424
IRB00307467
  • Ages 18-55
  • Female

Study Summary

Delayed cord clamping is a routine technique used in the delivery room. The baby remains attached to the umbilical cord and placenta for 30-60 seconds after birth to allow for maximal transfer of oxygen and blood to the newborn. This study seeks to determine the best position (on the back versus on the belly) for the newborn during the 30-60 seconds of delayed cord clamping.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Pregnant patient admitted for diagnosis that could result in a preterm delivery

  • Anticipated gestational age of delivery could be between 25w+0d - 29w+6d

  • Fetus without major anomalies or known genetic condition that could impactrespiratory status or need for intubation at birth

  • Singleton or twin gestation

  • Neonate eligible for delayed cord clamping based on institutional protocol

  • Patient is able to understand study procedures and is willing and able to consent

Exclusion

Exclusion Criteria:

  • Triplet or higher order gestation

  • Maternal or fetal/neonatal contraindication to delayed cord clamping

  • Major fetal anomaly that would be expected to impact delivery room intubation ratessuch as:

  • Major congenital cardiac defect (not isolated atrial septal defect/ventricularseptal defect)

  • Significant fetal arrhythmia at the time of delivery

  • Fetal tumor

  • Renal anhydramnios (not isolated urinary tract dilation with normal fluid)

  • Congenital Diaphragmatic Hernia

  • Heterotaxy

  • Moderate to severe ventriculomegaly or other major brain malformation (not mildisolated ventriculomegaly)

  • Airway obstruction

  • Underlying genetic disease that could impact respiratory function at delivery

  • Arthrogryposis (not apparently isolated clubbed foot)

  • Skeletal dysplasia

  • Pregnant patient is unable to understand study materials or is unwilling or unableto consent

  • Acute maternal obstetric emergency that precludes time or maternal focus for theconsent process to take place

Study Design

Total Participants: 89
Treatment Group(s): 2
Primary Treatment: Prone Positioning
Phase:
Study Start date:
August 09, 2022
Estimated Completion Date:
August 31, 2028

Study Description

This study is being done to see if placing babies on the stomach or the back during delayed cord clamping after birth will improve the outcomes of preterm babies. Studies have shown that in some instances, positioning on the belly may help newborns clear their respiratory secretions. Research has shown that preterm babies can have improved breathing and require less support when placed on the stomach (prone position) rather than the back (supine position). Currently there are no guidelines for the best position for neonates to be in while receiving delayed cord clamping. The investigators are hoping to complete a research study to determine if placing preterm babies on their stomachs during the time of delayed cord clamping will improve the breathing of preterm babies and reduce the need for additional oxygen support with a breathing tube (endotracheal intubation). Depending on the outcomes of the study, the investigators are hoping to determine which position results in better outcomes for babies in both the delivery room and in the neonatal intensive care unit. If the investigators are able to determine the optimal position in this study, the investigators hope to improve the outcomes for future babies that are born preterm by placing the baby in the optimal position during delayed cord clamping.

Connect with a study center

  • Johns Hopkins University

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Johns Hopkins University

    Baltimore 4347778, Maryland 4361885 21287
    United States

    Site Not Available

  • West Penn Hospital-Allegheny Health Network

    Pittsburgh, Pennsylvania 15224
    United States

    Site Not Available

  • West Penn Hospital-Allegheny Health Network

    Pittsburgh 5206379, Pennsylvania 6254927 15224
    United States

    Site Not Available

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