Efficacy and Safety of Astragalus for Non-motor Symptoms of α-Synucleinopathy

Last updated: September 11, 2023
Sponsor: Fujian Medical University Union Hospital
Overall Status: Active - Recruiting

Phase

2

Condition

Dyskinesias

Parkinson's Disease

Dystonia

Treatment

Astragalus

Physical therapy group

Clinical Study ID

NCT05506891
AS-PDS
  • Ages 30-85
  • All Genders

Study Summary

α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of α-synucleinopathy, especially autonomic dysfunctions such as orthostatic hypotension. Efficacy and safety of astragalus for non-motor symptoms of α-synucleinopathy will be assessed by an open-label self-controlled before-and-after study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants with a clinical diagnosis of PD, MSA and DLB, with orthostatichypotension.
  • Participants with cognitive disorder.
  • Adults signed informed consents.

Exclusion

Exclusion Criteria:

  • Patients with history of astragalus allergy.
  • Patients with secondary Parkinsonism that cannot be excluded.
  • Patients with diseases that may cause other types of hypotension or similarsymptoms/signs because of hypotension
  • Patients with other medical conditions requiring treatments that may affect bloodpressure.
  • Patients with other neurological disorders.
  • Patients with serious comorbidities and immune diseases.
  • Uncooperative patients.
  • Pregnant or lactating women.

Study Design

Total Participants: 40
Treatment Group(s): 2
Primary Treatment: Astragalus
Phase: 2
Study Start date:
October 01, 2023
Estimated Completion Date:
July 01, 2024

Connect with a study center

  • Fujian Medical University Union Hospital

    Fuzhou, Fujian 350000
    China

    Active - Recruiting

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