Accuracy of Endomyometrial Biopsy in Diagnosis of Adenomyosis

Last updated: October 8, 2024
Sponsor: Ain Shams University
Overall Status: Completed

Phase

N/A

Condition

Dysfunctional Uterine Bleeding

Endometriosis

Treatment

hysteroscopic guided endomyometrial biopsy

Clinical Study ID

NCT05505656
MD 129/ 2022
  • Ages 20-50
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study will compare the accuracy of diagnosing adenomyosis by obtaining hysteroscopic guided endomyometrial biopsy and comparing it to accuracy of diagnosis by transvaginal ultrasound and magnetic resonance imaging.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients diagnosed with abnormal uterine bleeding due to adenomyosis diagnosed bytransvaginal ultrasound and mri and scheduled for hysterectomy

Exclusion

Exclusion Criteria:

  • hysterectomy not performed

  • incomplete ultrasound and mri information

Study Design

Total Participants: 70
Treatment Group(s): 1
Primary Treatment: hysteroscopic guided endomyometrial biopsy
Phase:
Study Start date:
June 09, 2022
Estimated Completion Date:
July 09, 2024

Study Description

Preoperative diagnosis of adenomyosis is usually difficult. The use of ultrasound and MRI for preoperative diagnosis is still of low positive predictive values. The majority of cases of adenomyosis are diagnosed postoperatively after justo pathological examination of the hysterectomy specimens.

The introduction of the concept of preoperative diagnosis of adenomyosis through a hysteroscopic endomyometrial biopsies may be a very good method for preoperative diagnosis of this condition. Participants patients who are diagnosed as adenomyosis by Ultrasound and MRI and scheduled for hysterectomy will undergo an endomyometrial biopsy. The accuracy of this method, its sensitivity, specificity, positive and negative predictive values of this method will be compared with the conventional methods for preoperative diagnosis of adenomyosis after final diagnosis by final gusto pathological diagnosis of hysterectomy specimens.

Connect with a study center

  • Ain Shams University Maternity Hospital

    Cairo,
    Egypt

    Site Not Available

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