Effect of Sacubitril/valsartan on Cardiac Function in Hypertensive Patients Stratified by BMI: a Real World Study

Last updated: February 11, 2025
Sponsor: Beijing Friendship Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Obesity

Diabetes Prevention

Circulation Disorders

Treatment

Sacubitril / Valsartan Oral Tablet [Entresto]

ACEI/ARB

Clinical Study ID

NCT05498675
2022-P2-173-01
  • Ages 18-70
  • All Genders

Study Summary

The purpose of this study is to investigate the effect of sacubitril/valsartan on cardiac function assessed by cardiac magnetic resonance (CMR) in hypertensive patients stratified by BMI.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with essential hypertension

  • 18-70 years old

  • No major barriers to provide written consent

Exclusion

Exclusion Criteria:

  • Secondary hypertension, except because of sleep apnea

  • cardiovascular disease (myocardial infarction, heart failure, stroke or coronaryrevascularization) within 6 months

  • Severe concomitant diseases (autoimmune disease, malignancy, late stage of liverdiseases, respiratory diseases and digestive diseases)

  • Unable to understand or comply with the study procedures

Study Design

Total Participants: 180
Treatment Group(s): 2
Primary Treatment: Sacubitril / Valsartan Oral Tablet [Entresto]
Phase:
Study Start date:
September 01, 2021
Estimated Completion Date:
June 30, 2027

Study Description

Obesity is one of the risk factors of hypertension, and affects cardiac structure and function in the long term for hypertensive patients. Sacubitril/valsartan is regarded as a better antihypertensive drug for the improvement of cardiac function for patients with heart failure, but it remains unclear whether there are differences among different BMI groups. Therefore, the aim of this study was to evaluate the benefit of sacubitril/valsartan versus other antihypertensive drugs on cardiac structure and function assessed by CMR in hypertensive patients stratified by BMI in the real world.

Connect with a study center

  • Beijing Friendship Hospital, Capital Medical University

    Beijing, Beijing 100050
    China

    Active - Recruiting

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