Randomized Trial Comparing Early "Trigger" Versus Delayed "Trigger" Timing in Cycles of Controlled Ovarian Stimulation.

Last updated: August 10, 2022
Sponsor: Fertility Center of Las Vegas
Overall Status: Active - Recruiting

Phase

N/A

Condition

Infertility

Treatment

N/A

Clinical Study ID

NCT05498350
FCLV-2022-1
  • Ages 18-34
  • Female
  • Accepts Healthy Volunteers

Study Summary

This randomized trial will compare the efficacy of two different times of administration of medications for final oocyte maturation, commonly called a "trigger", in cycles of controlled ovarian stimulation (COS) for cycles in which all embryos will be cryopreserved ("freeze-all cycles").

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Adult female at least 18 years of age and less than 35 years of age intending toundergo ovarian stimulation for a cycle of IVF with all embryos to be frozen thatattain the blastocyst stage.
  2. Anticipated at least normal ovarian response evidenced by at least 8 antral folliclesobserved on ultrasound or a serum level of at least 1.5 ng/ml AMH.
  3. Ability read and understand English sufficiently to obtain informed consent.
  4. Patients with prior IVF cycles are allowed, but no patient can undergo more than onecycle with oocyte collection under this study.

Exclusion

Exclusion Criteria:

  1. Any cycle type that would preclude immediate culture to blastocyst stage (e.g. oocytebanking).
  2. Any condition that, in the opinion of the physician or principal investigator, wouldplace the patient at undue risk under this protocol or would otherwise make theprotocol inappropriate for that subject.

Study Design

Total Participants: 150
Study Start date:
August 10, 2022
Estimated Completion Date:
November 30, 2025

Study Description

This randomized trial will compare the efficacy of two different times of administration of medications for final oocyte maturation, commonly called a "trigger", in cycles of controlled ovarian stimulation (COS) for cycles in which all embryos will be cryopreserved ("freeze-all cycles").

  1. The early trigger timing will be based on sonographic observation of at least three follicles reaching at least 17mm in diameter.

  2. The delayed trigger timing will be based on at least three follicles reaching at least 22mm in diameter.

Connect with a study center

  • Fertility center of Las Vegas

    Las Vegas, Nevada 89117
    United States

    Active - Recruiting

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