Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

Key Inclusion Criteria:

1. History of cirrhosis based on histology or a combination of clinical, radiological,or biochemical assessment and classified as Child-Pugh A or B

2. Participants may be male or female aged 18 to 75 years.

3. Body mass index (BMI) within the range 18 to 40 kg/m2 (inclusive) at screening.

4. Female participants must be non-pregnant, non-lactating, or of non-childbearingpotential or using highly efficient contraception for the full duration of the study

Key Exclusion Criteria:

1. Significant abnormalities in medical history or on physical examination, including:respiratory disease requiring therapy or history of respiratory failure,cardiovascular disease or hypertension, electrocardiogram abnormalities or historyof significant EKG abnormalities.

2. History of diabetes insipidus, syndrome of inappropriate antidiuretic hormonesecretion, or any other disorder associated with fluid or sodium imbalance.

3. Significant kidney disease

4. Hepatic encephalopathy (HE) or altered mental status requiring hospitalization;variceal bleeding or upper gastrointestinal bleeding; or type 1 hepatorenal syndromewith acute kidney injury (HRS-AKI) during the previous 3 months prior to Screening.

5. Acute-on-chronic liver failure.

6. Recipient of a patent transjugular intrahepatic portosystemic shunt (TIPS).

7. Known positive HIV serology confirmed by HIV viral load.

8. Subjects with acute infections, including acute viral hepatitis (subjects withchronic hepatitis B are eligible if treatment regimen is stable ≥ 3 months prior tostudy inclusion).