Tau And Connectomics In TES Study

Inclusion Criteria:

• The participant must have full capacity to understand the purpose and risks of thestudy to provide informed consent.
• All participants must be between 40 to 70 years of age.
• Must meet the Traumatic Encephalopathy Syndrome criteria as defined by the NationalInstitute of Neurological Disorders and Stroke Consensus Diagnostic Criteria forTraumatic Encephalopathy Syndrome, Katz. D, et. al. Neurology, 2021.
• Participants must demonstrate that they have a cognitive decline, evident byperformance on neuropsychological testing.
• Standard of care blood screening within 12 months of consent to the study to excludeother medical conditions which may cause cognitive decline, such as heavy metaltoxicology.
• A PET scan within 6 months of consent to the study that is not consistent withAlzheimer's disease.
• Participants must consent to undertake Positron Emission Tomography (PET) withintravenous [18F] PI-2620 PET tracer ligand.
• Participants must be able to lie still, on their back for up to 60 minutes for thescans.
• Participants must not have any metal in their bodies e.g. pacemakers, aneurysm clipswhich are contraindications of MRI.
• Participants must consent to the use of their medical records and medical history,including but not limited to pathology results, previous imaging results andneuropsychology results

Exclusion Criteria:

• Participants will be excluded if they do not meet all the inclusion criteria.
• Participants must not be diagnosed with or suspected to be suffering from any otherneurodegenerative disease, or cerebral disease affecting cognition as identified byresults of neuropsychological evaluation or neurologist consultation.
• Participants will be excluded if Staff at Macquarie Medical Imaging determine that theparticipant is not suitable for imaging, for any reason.
• Participants will be excluded if they have kidney and/or liver dysfunction asdiagnosed by a doctor