Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY

Inclusion Criteria:

• Adult patients, and minor patients ≥ 2 years old diagnosed with LGS, DS or TSC.

• Clinical decision, taken by the physician, to initiate Epidyolex®

• Adult participants, parents or legal representatives must be willing and able togive informed consent/assent for participation in the study.

Exclusion Criteria:

• Participants currently using or have used recreational, medicinal cannabis, orcannabinoid-based products within the three months prior to study entry and areunwilling to abstain from these products for the duration of the study.

• Any reason, according to Investigator's judgment, able to compromise compliance withprocedures outlined in the study There will not be any other specific exclusioncriteria; however, contraindications, special warnings, and precautions for use asdetailed in the Summary of Product Characteristics (SmPC) (particularly related toraising of aspartate aminotransferase [AST], alanine aminotransferase [ALT], andtotal bilirubin) will have to be considered by the treating physician.