Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)

Inclusion Criteria:

1. Individuals who are 20 to 40 years old.
2. The concentrations of anti-Mullerian hormone < 1.1 ng/ml, the values of antralfollicle count range from less than 5 to less than 7 and two recordings of serumconcentrations of day-3 follicle-stimulating hormone (FSH) ≥10 IU/L.
3. Individuals who can insist on continuous monitoring in the outpatient clinic.
4. Individuals who are not participating in other research projects currently or 3 monthsbefore the intervention.

Exclusion Criteria:

1. Individuals who are during pregnant, lactation or menopause.
2. Individuals who had non-46-XX karyotype, or attributed to known genetic etiology.
3. Individuals who had pelvic surgery.
4. Cancer patients or receiving chemo/radiotherapy treatment within the past 5 years.
5. Individuals who need regular medication to treat chronic diseases such as diabetes,hypertension, gout, hyperuricemia, etc.
6. Individuals who currently receiving weight-loss drugs or surgery or within the past 2months.
7. Use of medications or traditional Chinese medicine that affect hormone levels,appetite, carbohydrate absorption, and metabolism within the past 3 months.
8. Individuals who take niacin, nicotinamide, or other vitamin B3-relatedsupplementation, or other supplementation such as coenzyme Q10, vitamin E currently orwithin the past 3 months.
9. Use of antibiotics, probiotics, or prebiotics that affect the flora within the past 3months.
10. Individuals with severe liver diseases or kidney disease that are ineligible toparticipate in the study.
11. A medical history of severe cardiovascular and cerebrovascular diseases.
12. Individuals who currently suffer from severe gastrointestinal diseases or undergogastrointestinal resection that may affect nutrient absorption.
13. Individuals who drink more than 15g of alcohol per day or have a smoking habit.
14. Individuals who need drug treatment for any mental illness such as epilepsy anddepression.
15. Individuals who suffer from infectious diseases such as hepatitis B, activetuberculosis, AIDS, etc.
16. Unable or unwilling to follow the study protocol.