Pamiparib for Consolidation Treatment of Unprogressed LS-SCLC After Concurrent Chemoradiotherapy

Inclusion Criteria:

• The patient or a legally authorized representative must provide study-specificinformed consent prior to study entry, had good compliance and cooperated with thefollow-up.
• Age at least 18 years
• Pathologically (histologically or cytologically) proven diagnosis of limited stagesmall cell lung cancer (Stage Tx, T1-T4, N0-3, M0, American Joint Committee on Cancer [AJCC] staging, 8th edition [Ed.]), within 60 days prior to registration
• Patients must have had measurable disease (per Response Evaluation Criteria in SolidTumors [RECIST], version 1.1) prior to the required cycle of cCRT
• Patients must be free of disease progression and not be able to receive otherantitumor therapy within 6 weeks of completion of cCRT
• Patients must submit archived or freshly biopsied tumor tissue (formalin-fixed,paraffin-embedded tissue block or approximately 15 unstained sections [must have >8sections]) along with the relevant pathology report.
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 30 daysprior to registration
• Patient life expectancy must be >12 weeks

Exclusion Criteria:

• Mixed SCLC or NSCLC confirmed by histology
• Previous tumor resection for LS-SCLC
• Any patient treatable by surgery or stereotactic body radiation therapy/stereotacticablative radiation therapy should be excluded
• Expected to receive any other form of anti-tumor therapy during the study period
• Previous treatment with PARP inhibitor drugs
• Any active malignancy within 2 years prior to enrollment, excluding the specificcancers being studied in this study and locally recurrent cancers that have been cured (eg, resected basal or squamous cell skin cancer, superficial bladder cancer, cervicalcancer carcinoma in situ or carcinoma in situ of the breast)
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study
• Concurrent participation in another therapeutic clinical trial