Immediate Versus Postponed Freeze-all Embryo Transfer in Hyperresponders

Last updated: November 24, 2024
Sponsor: Peking University Third Hospital
Overall Status: Completed

Phase

N/A

Condition

In Vitro Fertilization

Treatment

the timing of embryo transfer in freeze-all cycles

Clinical Study ID

NCT05483270
Delay-ET-RCT
  • Ages 20-42
  • Female
  • Accepts Healthy Volunteers

Study Summary

This is a multicenter, randomised controlled trial. The investigators plan to randomise 836 participants to the immediate FET or the postponed FET from the day of oocyte retrieval to the last day of that menstrual cycle in a 1:1 rate. Primary outcome will be the live birth rate after the embryo transfer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women aged 20 to 42 years old;

  • Written informed consent;

  • Women scheduled for freeze-all embryo transfer;

  • Women with the number of oocyte collected higher than 15.

Exclusion

Exclusion Criteria:

  • Women with a history of at lease three failed transfer cycles;

  • Women with an endometrial thickness less than 7 mm on the triggering day;

  • Severe uterine malformations.

Study Design

Total Participants: 845
Treatment Group(s): 1
Primary Treatment: the timing of embryo transfer in freeze-all cycles
Phase:
Study Start date:
August 30, 2022
Estimated Completion Date:
November 24, 2024

Study Description

It is postulated that postponing embryo transfer for at least one menstrual cycle after a freeze-all cycle can minimise the possible residual negative effect caused by ovarian stimulation and can promote the resumption of a normal ovulatory cycle and the receptivity of endometrium. Nevertheless, emerging evidence suggests a higher live birth rate in the immediate freeze-all embryo transfer (FET) cycles compared to that in the delayed group. It is unclear the whether postponed FET is superior in hyperresponders. The investigators hypothesize the success rate in the postponed FET for at least one menstrual cycle after oocyte retrieval is higher than in the immediate FET in hyperresponders.

Objective: To evaluate whether the postponed FET for at least one menstrual cycle after oocyte retrieval is superior to the immediate FET in the first menstrual cycle after oocyte retrieval in hyperresponders in terms of live birth rates.

Design: a multicenter, randomised controlled trial Patients: The investigators plan to randomise participants to the immediate FET and the postponed FET from the day of oocyte retrieval to the last day of that menstrual cycle.

Primary outcome: live birth rate after the embryo transfer. Patients who get pregnant will be followed up until 6 weeks after delivery.

Sample size: The investigators plan to enroll 836 participants in a 1:1 rate.

Connect with a study center

  • Peking university third hospital

    Beijing, 100191
    China

    Site Not Available

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