Feasibility Study of an Innovative Medical Device for Sampling the Contents of the Small Intestine.

Inclusion Criteria:

• Able to understand the study and the associated instructions

• Aged ≥18 years and ≤65 years

• Fasting with water and food for at least 10 hours

• BMI between ≥20 and ≤30 kg/m².

• Transit evaluated at 1 to 3 bowel movements/day

• Maintain regular physical activity and eating habits for the duration of the study

• Affiliated with a social security plan

• Have a freezer in their home and at work, if applicable

• Volunteer staying in the Isère department during the collection of the faeces (from 96 hours to 15 days max)

• Having signed the informed and collection consent

Exclusion Criteria:

Subject :

• with medical treatment (except oral contraception and/or probiotics and relatedproducts)

• with lactose and fructose intolerance

• with of gastroparesis

• who had a colonoscopy preparation up to 1 month prior to inclusion

• in the exclusion period of another clinical investigation,

• who receive more than 4500 euros of compensation due to his participation in otherbiomedical research in the 12 months preceding this study

• who cannot be contacted in case of emergency

• who has taken during the 15 days prior to inclusion and/or is scheduled to take thefollowing treatments during the study: antidepressants, anxiolytics,antiparkinsonian agents, neuroleptics, antibiotics and prebiotics

• who has taken during the previous 7 days: at least once a treatment for irritablebowel syndrome (antispasmodics,..) or for constipation (laxative) or for diarrhea

• with a known food allergy

• who have to undergo colon surgery

• with intestinal obstruction history

• with hepatic, cardiac, congenital or renal comorbidity

• with long-standing diabetes

• with an inflammatory disease of the digestive tract, a history of digestive surgery

• who have been treated with radiotherapy or who have taken anti-inflammatory drugsfor a long time

• with gastric fullness

• with known or suspected obstruction of the gastrointestinal tract (including knowninflammatory bowel or intestinal diverticula)

• with presence of swallowing disorders or Zencker's diverticulum

• with nausea, deviated nasal septum

• with contraindications to esophageal tube placement (chronic esophageal pathology)

• drug or alcohol abuse (3 units for men and 2 units for women according to WHOcriteria)

• with a known allergy to silicone or to iodine

• refusing medical imaging or surgery (in case of non-recovery of the capsule)

• protected person concerned by the articles L1121-5 to L1121-8 of the Public HealthCode

• absence of highly effective contraception for women with childbearing capacity untilthe end of the cycle following the end of participation in the trial