Taiwan Associated Genetic and Nongenetic Small Vessel Disease

Last updated: December 19, 2024
Sponsor: National Taiwan University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Fabry Disease

Hemorrhage

Stroke

Treatment

MRI

Clinical Study ID

NCT05473637
201911029RINB
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Participants must have at least one of the following symptoms/signs or history

  • stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICHor young stroke)

  • cognitive impairment or dementia

  • gait disturbance

  • parkinsonism (especially vascular parkinsonism features)

  • headache (especially migraine)

  • positive family history of hereditary CSVD

  • MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderatewhite matter hyper intensity, any lacune, or any cerebral microbleed

Exclusion

Exclusion Criteria:

  • MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions

  • patients or family members not willing to sign informed consent

Study Design

Total Participants: 500
Treatment Group(s): 1
Primary Treatment: MRI
Phase:
Study Start date:
January 01, 2019
Estimated Completion Date:
December 31, 2028

Connect with a study center

  • Department of Neurology, National Taiwan University Hospital

    Taipei, 100
    Taiwan

    Active - Recruiting

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