TCA 15% Chemical Peel for Improvement in Hand Lentigines

Last updated: March 14, 2025
Sponsor: Main Line Center for Laser Surgery
Overall Status: Completed

Phase

4

Condition

Skin Aging

Treatment

15% Trichloroacetic acid + 3% glycolic acid

Clinical Study ID

NCT05471947
SC20220721
  • Ages > 22
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study will evaluate the efficacy of the a 15% trichloroacetic acid + 3% glycolic acid peel combination for treatment of lentigines on the hands. This peel combination is sold over the counter. Patients will receive 3 treatments (spaced 4 weeks).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age >21

  • No laser, chemical peel, neuromodulator, filler treatment to the hands in >3 months

  • At least 5 lentigines on each hand

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Breastfeeding

  • Allergy to trichloroacetic acid

  • Allergy to glycolic acid

  • Open wounds on treatment area (hands)

  • Active inflammatory disease on treatment area such as atopic dermatitis, psoriasis,dermatomyositis

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: 15% Trichloroacetic acid + 3% glycolic acid
Phase: 4
Study Start date:
March 15, 2023
Estimated Completion Date:
December 01, 2024

Study Description

This clinical investigation is a prospective study consisting of a screening visit, 3 treatment visits, and 1 follow-up visit. Baseline and post-treatment photos will be graded and compared.

A total of 20 patients will be recruited. Following informed consent and screening, subjects' dorsal hands will be photographed.

Patients will receive 3 treatments with the 15% TCA + 3% glycolic acid peel every 4-6 weeks on the dorsal hands. Post-treatment, patients will be instructed to apply Aquaphor to the treated area twice daily for 5 days. Patients' hands will be photographed at each visit.

Four to six weeks after their final treatment, subjects will return for photography.

Connect with a study center

  • Main Line Center for Laser Surgery

    Ardmore, Pennsylvania 19003
    United States

    Site Not Available

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