Isolation, Characterization and Evaluation of the Potential of TissuE-resideNt cElls From Waste Musculoskeletal and Associated Connective Tissues

Last updated: July 20, 2022
Sponsor: Istituto Ortopedico Galeazzi
Overall Status: Active - Recruiting

Phase

N/A

Condition

Musculoskeletal Diseases

Treatment

N/A

Clinical Study ID

NCT05471752
TENET(L4165)
  • Ages > 18
  • All Genders

Study Summary

The general purpose of this study is characterization of tissue-resident cells derived from different musculoskeletal and/or associated connective tissues (such as cartilage, synovial membrane, synovial fluid, bone, adipose tissue and tendons), in order to identify new strategies for the treatment of degenerative and inflammatory musculoskeletal disorders. Cells isolated from different tissue sources will be compared with each other by phenotypic and functional characterization, following culture and treatment with inflammatory elements, drugs and orthobiologics. Moreover, with the aim to assess predictive markers of therapeutic success, a correlation study of the content and properties of the cells isolated from different types of tissue with the clinical profile of the enrolled patients will be conducted.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • males and females
  • 18 years old
  • patients undergoing elective surgery at IRCCS Istituto Ortopedico Galeazzi among whichjoint surgery (including hip or knee replacement), or anterior cruciate ligament (ACL)reconstruction or rotator cuff repair

Exclusion

Exclusion Criteria:

  • age < 18 years old
  • patients unable to sign the Informed Consent
  • positivity to virological test (HIV, HCV, HBV, TPHA)

Study Design

Total Participants: 742
Study Start date:
May 11, 2022
Estimated Completion Date:
May 11, 2027

Connect with a study center

  • IRCCS Istituto Ortopedico Galeazzi

    Milan, 20161
    Italy

    Active - Recruiting

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