Effect of Estrogen Treatment on Drug Metabolism and Transport

Last updated: January 7, 2026
Sponsor: University of Washington
Overall Status: Completed

Phase

4

Condition

N/A

Treatment

Midazolam oral solution

Digoxin Oral Tablet

Acetaminophen Oral Tablet

Clinical Study ID

NCT05469204
STUDY00014091
1K23GM147350
  • Ages 18-55
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This project will evaluate the effect of estrogen treatment on how other medications are processed by the body.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Self-identified trans* adult 18-55 years of age.

  • Not taking estradiol treatment currently.

  • Planning to start injectable estradiol or estradiol tablets for gender-affirmingmedical care.

Exclusion

Exclusion Criteria:

  • Unwilling/unable to return for project follow-up visits.

  • Unwilling/unable to provide written informed consent.

Study Design

Total Participants: 22
Treatment Group(s): 4
Primary Treatment: Midazolam oral solution
Phase: 4
Study Start date:
November 01, 2022
Estimated Completion Date:
July 30, 2025

Study Description

Estradiol is prepared as a medication that patients may take to increase hormone levels. Changes in estradiol concentrations in the body may affect how the body processes other medicines. The purpose of this study is to find out how estradiol therapy affects a single tracer dose of approved medicines in the blood (midazolam, digoxin, and acetaminophen) and to confirm estradiol treatment does not affect natural bacterial in the gut.

Connect with a study center

  • University of Washington

    Seattle, Washington 98195
    United States

    Site Not Available

  • University of Washington

    Seattle 5809844, Washington 5815135 98195
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.