The Global Cardiovascular Risk Consortium

Last updated: March 25, 2025
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Angina

Diabetes Prevention

Treatment

N/A

Clinical Study ID

NCT05466825
GCVRC001
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The Global Cardiovascular Risk Consortium (GCVRC) brings together harmonized individual-level data from over 2 million individuals across 133 cohorts, 39 countries, and 6 continents, with recruitment ongoing. The GCVRC examines the impact of classical cardiovascular risk factors-such as body mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes-on cardiovascular disease (CVD) and death from any cause worldwide.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Population-based individual-level data with available information on the classical cardiovascular risk factors including body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes, as well as the outcomes of interest.

Exclusion

Exclusion Criteria:

  • Participants with age below 18 years

  • No information on the outcome of interest

  • No information on the exposure of interest (CVD risk factors)

  • History of CVD at baseline

Study Design

Total Participants: 2500000
Study Start date:
September 20, 2019
Estimated Completion Date:
June 30, 2028

Study Description

A small number of modifiable risk factors may account for a significant proportion of cardiovascular disease (CVD) risk. However, the CVD burden attributable to classical risk factors depends on the populations studied and the methodologies used.

The Global Cardiovascular Risk Consortium (GCVRC) is an international collaboration that continuously includes cohort studies from around the world to improve cardiovascular risk prediction. The GCVRC uses extensively harmonized individual-level data from currently more than 2 Mio individuals from 133 cohorts, 39 countries and 6 continents categorized in 8 geographical regions (based on a modification of WHO and United Nations definitions)

  • North America, Latin America, Sub-Saharan Africa, North Africa and the Middle East, Western Europe, Eastern Europe and Russia, Asia, and Oceania.

The consortium has a special focus on classical, potentially modifiable cardiovascular risk factors: Body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes. Key research questions include examining the impact of these factors on major outcomes by geographical region and sex, as well as estimating associated lifetime risk and the potential lifetime difference when modifying these risk factors.

This work is critical for developing regionally tailored CVD prevention and treatment strategies, identifying residual risk, and improving global cardiovascular health. Based on GCVRC data, a landmark paper on the effect of classical risk factors on new-onset CVD and all-cause mortality was published in the New England Journal of Medicine in 2023 (https://doi.org/10.1056/nejmoa2206916).

Connect with a study center

  • University Medical Center Hamburg-Eppendorf

    Hamburg, 20251
    Germany

    Active - Recruiting

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