Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions

Inclusion Criteria

• Resident of the United States

• Females and males ages 25-75 (inclusive)

• Able to speak and read English

• No unexplained weight loss, fevers, anemia, or blood in stool

• Willing and able to follow the trial instructions, as described in the recruitment letter

• Signed and dated informed consent prior to any trial-specific procedures.

• Diagnosis of IBS according to ROME IV criteria AND IBS-SSS score of 125-450 (inclusive)

Exclusion criteria

• Unwilling to change current diet

• Prior use of Viome products or services

• Antibiotic use in the previous 4 weeks

• Women who are pregnant (current or planned in the next 4 months), or breastfeeding

• < 90 days postpartum

• Active infection

• Unable or unwilling to use Viome's App on an iPhone or Android smartphone

• Significant diet or lifestyle changes in the previous 1 month

• IBD diagnosis

• Use of investigational drugs, products or devices within 1 month prior to and 4 months after the start of the trial

• Cancer therapy within the previous 1 year

• Major surgery in the last 6 months or planned in the next 4 months

• Prescribed any drug(s) that may interact with the supplement formulations

• Have any medical condition or allergy that may interact with, or prevents the healthy consumption of the supplements

• Allergies to any study-specific supplement ingredients

• Currently on a specific diet:

FODMAP KETO PALEO

• Gastrointestinal disease including: Esophagitis Celiac disease GI malignancy or obstruction Peptic ulcer Duodenal or gastric ulcer disease

• GI surgery except:

Appendectomy and benign polypectomy