Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)

Inclusion Criteria:

• Participants with documented histopathological diagnosis of locally advanced ormetastatic colorectal cancer (CRC), who were intolerant/refractory to or progressedafter standard systemic therapies for the advanced/metastatic stage, if locallyindicated and available to the participant. Participants with a known microsatelliteinstability high (MSI-H) status must have received treatment with an immunecheckpoint inhibitor (if locally indicated and available) unless contraindicated.

• Eastern Cooperative Oncology Group Performance Status (ECOG PS) below or equal to 1

• Participants with adequate hematologic, hepatic and renal function as defined inprotocol

• Other protocol defined inclusion criteria could apply

Exclusion Criteria:

• Participant has a history of malignancy within 3 years before the date of enrollment (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situof the cervix, benign prostate neoplasm/hypertropia, or malignancy that in theopinion of the Investigator, with concurrence with the Sponsor's Medical Monitor, isconsidered cured with minimal risk of recurrence within 3 years)

• Participants with known brain metastases, except those meeting the followingcriteria: Brain metastases that have been treated locally and are clinically stablefor at least 4 weeks prior to the start of treatment; No ongoing neurologicalsymptoms that are related to the brain localization of the disease (sequelae thatare a consequence of the treatment of the brain metastases are acceptable)

• Participants with diarrhea (liquid stool) or ileus Grade > 1

• Participants with active chronic inflammatory bowel disease (e.g., ulcerativecolitis, Crohn's disease, intestinal perforation) and/or bowel obstruction

• Unstable angina, myocardial infarction, congestive heart failure (New York HeartAssociation [NYHA] >= II) or a coronary revascularization procedure within 180 daysof study entry. Calculated QTc average (using the Fridericia correction calculation)of > 470 milliseconds (ms)

• Cerebrovascular accident/stroke (< 6 months prior to enrollment)

• Other protocol defined exclusion criteria could apply