Last updated: July 18, 2022
Sponsor: Peking Union Medical College Hospital
Overall Status: Active - Not Recruiting
Phase
4
Condition
Low Blood Pressure (Hypotension)
Treatment
N/AClinical Study ID
NCT05463471
PUMCH-ICU-LY
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Age ≥ 18 years old, gender unlimited
- Shock requires volume resuscitation: Insufficient tissue perfusion: wet and cold skin, decreased urine volume (<0.5ml/kg/h), change of consciousness, blood lactate >2.0mmol/l or vasoactive drugsare required to maintain map>65mmhg
- Presence of volume reactivity: (under controlled ventilation) PPV ≥ 15% or passive legraising test (+) or (under controlled ventilation) IVC variability ≥ 18% or thepresence of volume reactivity as judged by clinicians
- The patient has no obvious restlessness, RASS ≤ 0
- The legal representative of the subject signs the informed consent form-
Exclusion
Exclusion Criteria:
- Pregnant and lactating women
- End stage patients
- BMI ≤ 15 or BMI ≥ 50
- Contraindication of indwelling central vein catheter and invasive arterial catheter
- Patients in ECMO and / or IABP therapy
- Hemorrhagic shock, blood products such as concentrated red blood cells, plasma andplatelets will be infused within 1 hour
- Myocardial infarction, NYHA grade IV
- Patients with hyperkalemia, hypercalcemia, hypermagnesemia and hypothyroidism
- Allergic to compound sodium acetate ringer injection or albumin or with known sideeffects
- Other factors that may affect the monitoring and evaluation of relevant indicators
Study Design
Total Participants: 500
Study Start date:
August 01, 2022
Estimated Completion Date:
December 12, 2027