Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation

Inclusion Criteria:

• Patients 18 years of age or older.
• Patients suffering from diarrhea-predominant IBS according to Rome III criteria.
• Active symptoms for at least 2 weeks
• Abdominal Pain Intensity: weekly average of worst daily (in past 24 hours) abdominalpain score of > 3.0 on a 0-to-10-point scale and Stool Consistency: at least one stoolwith a consistency of Type 6 or Type 7 Bristol stool score (BSS) on at least 2 daysper week
• Report no restriction whatsoever on their diet.

Exclusion Criteria:

• Presence of liver disease, malignancy, severe malabsorption, bedridden,endocrinological disorders, or severe chronic obstructive pulmonary disease.
• Patients who have undergone abdominal surgeries except for appendectomy and/orcholecystectomy and/or hysterectomy.
• Patients who consumed any medications that may affect bowel function within the last 2weeks such as antibiotics, probiotics, prebiotics, antispasmodics, antidiarrheals,narcotics, or any other medication that may alter bowel function
• Patients on antidepressants or antipsychotics starting within the last six weeksbefore eligibility check.