Depression and Driving

Last updated: July 24, 2023
Sponsor: Ganesh Babulal
Overall Status: Active - Recruiting

Phase

N/A

Condition

Depression

Treatment

F 18 AV-1451 (Flortaucipir)

[11C]-Pittsburgh Compound B ([11C]PiB)

Clinical Study ID

NCT05446805
202003209
  • Ages > 65
  • All Genders

Study Summary

This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Drive on average at least once per week
  • Has a valid driver's license
  • Willing to complete blood draw
  • Willing to complete either lumbar puncture or PET imaging
  • 65 years or older
  • Speaks English

Exclusion

Exclusion Criteria:

  • Not willing to complete blood draw and/or one other biomarker
  • Less than 65 years of age
  • Does not drive a vehicle/ is no longer actively driving

Study Design

Total Participants: 150
Treatment Group(s): 2
Primary Treatment: F 18 AV-1451 (Flortaucipir)
Phase:
Study Start date:
June 17, 2021
Estimated Completion Date:
December 17, 2026

Study Description

The long-term goal is to accurately identify who is at risk of decline in driving, to forecast when decline will occur, and to intervene before decline, thereby reducing the numbers of crashes, injuries, and death in older adults. The findings indicate that the long preclinical stage of Alzheimer disease (AD), as reflected in amyloid imaging and cerebrospinal fluid (CSF) biomarkers among cognitively normal participants, is associated with poorer driving performance on a standardized road test. This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

Connect with a study center

  • Washington University School of Medicine

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

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