Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease

Inclusion Criteria:

• Retrospective Phase:

• Adults aged 40 or older.

• At least 1 ECG obtained during routine clinical care.

• Prospective Phase:

• AF Cohort:

• Adults aged 65 or older at the time of ECG.

• ECG obtained as part of a clinical care.

• Patient is able to identify a licensed healthcare provider to receive the results ofthe patch monitor.

• SHD Cohort:

• Adults aged 40 or older at the time of the ECG.

• ECG obtained as part of a clinical care between study start date and the end ofstudy recruitment

• Patient is able to identify a licensed healthcare provider to receive the results ofthe echocardiogram.

Exclusion Criteria:

• Retrospective Phase:

• Patients who have previously requested that their data not be involved in anysecondary use application such as a research study.

• Prospective Phase:

• AF Cohort:

• Any clinical or social factor that would prohibit completing the follow-up studiesin a timely fashion.

• Patient currently admitted to the hospital (at time of consent)

• Permanent pacemaker or implanted cardiac defibrillator or implanted loop recorder.

• History of atrial fibrillation or atrial flutter.

• Cardiac surgery within 30 days prior to the index ECG

• Cardiac surgery planned within the next 6 months.

• Allergy to adhesive.

• SHD Cohort:

• Any clinical or social factor that would prohibit completing the follow-up studiesin a timely fashion.

• Patient currently admitted to the hospital (at time of consent).

• History of SHD defined as any of the following: severe mitral regurgitation, severetricuspid regurgitation, moderate or severe aortic stenosis, moderate or severeaortic regurgitation, moderate or severe mitral stenosis, left ventricular systolicdysfunction (LVEF ≤ 40%), or increased septal wall thickness > 15 mm.

• Allergy to ultrasound gel.