Decoding and Modulating Affective Brain States

Last updated: August 26, 2025
Sponsor: University of Pennsylvania
Overall Status: Active - Recruiting

Phase

N/A

Condition

Depression

Depression (Major/severe)

Anxiety Disorders

Treatment

Transcranial Magnetic Stimulation

Clinical Study ID

NCT05437705
850664
  • Ages 18-65
  • All Genders

Study Summary

The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.

Eligibility Criteria

Inclusion

Inclusion criteria:

  1. 18-65 years old

  2. Patient Health Questionnaire (PHQ-9 score) = or > than 10

  3. Comprehension of instructions in the English language.

  4. Capacity to provide informed consent and follow study procedures.

  5. Availability for the duration of the study.

Exclusion

Exclusion Criteria:

  1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychoticdisorder

  2. Recent use of psychoactive medications or substances as determined by investigators

  3. History of neurological disorder or traumatic brain injury (other than mild)

  4. Unable to have an MRI scan, or current or prior medical condition that couldinterfere with the collection or interpretation of MRI data

  5. Unable to receive or tolerate TMS

  6. Implanted devices, such as an aneurysm clip or cardiac pacemaker

  7. History of stroke, epilepsy, or brain scarring

  8. Pregnant, nursing, or trying to become pregnant (self-attestation alone)

During this study, participants are asked to:

  1. Refrain from substance use (including marijuana and illicit drugs) for duration ofthe study (self-attestation alone).

  2. Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).

  3. Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: Transcranial Magnetic Stimulation
Phase:
Study Start date:
February 21, 2023
Estimated Completion Date:
December 01, 2028

Study Description

The study involves 11 visits over approximately 10 weeks, depending on scanner availability and scheduling. See below for the study schedule with a summary of the procedures:

  • Visit 1: Screening Procedures (3-4 hours). The first part of the screening will take place remotely (1 hour). The investigators will begin by reviewing the Informed Consent Form (ICF). Participants who agree to participate and sign the ICF will then complete several questionnaires. Those who meet preliminary eligibility criteria based on the remote procedures will be invited for an in-person visit. The in-person screening will include a brief TMS demonstration (20 minutes). If TMS is well tolerated, the visit will proceed to a comprehensive clinical interview (2-3 hours) to assess current and past mental health history.

  • Visit 2: Baseline MRI & Assessments (~2 hours). This visit will involve a 1-hour MRI scan, including both structural and functional sequences, and an assessment session with computerized tasks and questionnaires.

  • Visit 3: MRI Scan with TMS (~2.5 hours). A second MRI scan will be conducted with concurrent TMS procedures. Participants will complete a mental task while interleaved rTMS is delivered at different frequencies. This scan will be used to determine the optimal stimulation frequency for each participant.

  • Visits 4-6: First Neuromodulation Session (~1.5 hours each). Participants will receive rTMS using either the optimal or least optimal stimulation frequency. They will also complete two computerized tasks after rTMS, with questionnaires in between procedures.

  • Visit 7: MRI Scan with TMS (~2 hours). This visit will be a shortened version of Visit 3, as some MRI scans and questionnaires will not need to be repeated.

  • Visits 8-10: Second Neuromodulation Session (~1.5 hours each). These visits will mirror Visits 4-6. However, the TMS condition administered (optimal or suboptimal frequency) will be counterbalanced with the condition used during the first neuromodulation session. Visit 8 will be scheduled at least 2 weeks after Visit 7.

  • Visit 11: MRI Scan with TMS (~2 hours). This visit will mirror Visit 7.

After completing all procedures, participants will receive the full study compensation. Payments may be issued earlier if participants request compensation after each visit or if they withdraw early.

Connect with a study center

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • University of Pennsylvania

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Active - Recruiting

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