Last updated: September 6, 2023
Sponsor: Belfast Health and Social Care Trust
Overall Status: Active - Recruiting
Phase
N/A
Condition
N/ATreatment
Ultrafiltration
Clinical Study ID
NCT05431491
21021JS-AS
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Adults (>18 years)
- Evidence of fluid overload (greater than trace amount of peripheral oedema in >1 site,pulmonary oedema on chest radiograph, or positive fluid balance equivalent to >5% bodyweight)
- Clinician intention to target a negative fluid balance
- Expected to remain in a critical care setting beyond the next calendar day
Exclusion
Exclusion Criteria: Anticipated unavailability of suitable vascular access
- Lack of commitment to full support
- Receiving or imminently planned to receive renal replacement therapy
- Hyponatraemia (Sodium <130mmol/L)
- Hypernatraemia (Sodium >150mmol/L)
- Significant metabolic alkalosis (Bicarbonate>30 and pH>7.5)
- Significant metabolic acidosis (HCO3- <18 mmol/l and pH < 7.30)
- Uncorrected hypokalaemia (Potassium <3.0mmol/L)
- Liver failure (Child-Pugh Grade B or above)
- Shock (any of: lactate >3mmol/L, extensive skin mottling, central capillary refilltime>3 seconds, more than 1 vasoactive agent in use, noradrenaline dose >0.2mcg/kg/min, use of dobutamine, adrenaline, milrinone, enoximone or levosimendan)
- Receiving any systemic anticoagulation other than for routine venous thromboembolismprophylaxis, or dual antiplatelet therapy
- Prisoner
- Known pregnancy
Study Design
Total Participants: 15
Treatment Group(s): 1
Primary Treatment: Ultrafiltration
Phase:
Study Start date:
August 12, 2022
Estimated Completion Date:
March 01, 2024
Study Description
Connect with a study center
Belfast City Hospital
Belfast, Down BT97AB
United KingdomActive - Recruiting
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