Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery

Last updated: March 26, 2025
Sponsor: University of Aarhus
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pancreatitis

Pancreatic Disorders

Cancer

Treatment

Preoperative MRI

Clinical Study ID

NCT05428358
MAGIPAC
  • Ages 18-99
  • All Genders

Study Summary

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Pancreatic cancer patients considered to have a locally resectable or borderlineresectable tumor by the local hepato-pancreato-biliary multidisciplinary team board

  • No liver metastases on CT

  • At least 18 years old and able to provide informed consent

  • Expected pancreatic ductal adenocarcinoma based on CT scan

Exclusion

Exclusion criteria:

  • Metastatic disease

  • Prior receipt of neoadjuvant chemotherapy or downstaging/-sizing treatment

  • Comorbidity rendering major surgery unfeasible (inoperable)

  • No informed consent

  • Unable to undergo MRI (Kidney insufficiency (eGFR < 60 ml/min/1.73 m2 body surfacear-ea); Claustrophobia; Cardiac pacemaker)

  • Postoperative histology other than adenocarcinoma of pancreato-biliary origin.

  • MRI with liver-specific contrast performed during standard workup.

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: Preoperative MRI
Phase:
Study Start date:
August 30, 2022
Estimated Completion Date:
December 01, 2028

Study Description

The aim of the study is to examine the incremental value of using magnetic resonance imaging (MRI) in addition to computed tomography (CT) in the diagnostic workup of pancreatic cancer patients. We will conduct a nationwide, prospective clinical trial to examine the incremental value of using MRI for identification of liver metastases in pancreatic cancer patients.

Connect with a study center

  • Aalborg University Hospital

    Aalborg,
    Denmark

    Active - Recruiting

  • Aarhus University Hospital

    Aarhus, 8200
    Denmark

    Active - Recruiting

  • Rigshospitalet

    Copenhagen,
    Denmark

    Active - Recruiting

  • Odense University Hospital

    Odense,
    Denmark

    Active - Recruiting

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