Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3

Last updated: March 6, 2025
Sponsor: Karolinska Institutet
Overall Status: Active - Recruiting

Phase

N/A

Condition

Angina

Congestive Heart Failure

Hypercholesterolemia

Treatment

Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

Clinical Study ID

NCT05426408
SMINC-3
  • Ages 35-79
  • All Genders

Study Summary

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiographywithout diameter stenosis ≥50%

  • age 35-80 years

  • reading and writing proficiency in Swedish

Exclusion

Exclusion Criteria:

  • Claustrofobia

  • Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)

  • Asthma or severe chronic obstructive lung disease

  • eGFR < 30 ml/min

  • spontaneous coronary artery dissection

  • acute pulmonary embolism

  • acute myocardial infarction type 2

  • cardiomyopathy other than takotsubo syndrome

  • a previous myocardial infarction due to CAD

Study Design

Total Participants: 85
Treatment Group(s): 1
Primary Treatment: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction
Phase:
Study Start date:
November 01, 2022
Estimated Completion Date:
June 30, 2026

Connect with a study center

  • Per Tornvall

    Stockholm, 11551
    Sweden

    Active - Recruiting

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